Marcus Mariota threw for two touchdowns and Derrick Henry ran for two scores as the Tennessee Titans led wire-to-wire Sunday in a 34-10 upset of the New England Patriots at Nissan Stadium in Nashville, Tenn.

Tennessee (5-4) moved within a game of idle Houston in the AFC South with its second home win against a Super Bowl team from last year. The Titans beat Philadelphia in overtime on Sept. 30, but didn't need to work quite that hard in this one.

Mariota, who completed 16 of 24 passes for 228 yards, started the onslaught just 3:31 into the game with a 4-yard touchdown pass to Jonnu Smith.

After Stephen Gostkowski bombed a 52-yard field goal just over two minutes later, Mariota made it 14-3 by lofting a 23-yard scoring strike to Corey Davis, who withstood pass interference by Stephon Gilmore to make the catch.

Ryan Succop's 33-yard field goal with 2:39 left in the quarter upped the Tennessee lead to 17-3.

New England (7-3) scored its only touchdown on its next possession, getting a 1-yard scoring run from fullback James Develin -- his first carry in four years -- at the 12:49 mark of the second quarter.

But the Titans regained momentum just before halftime with Henry's 1-yard touchdown run 1:09 before the break, capping a 37-yard drive and making it 24-10.

Succop converted a 31-yard field goal with 4:19 left in the third quarter to increase the lead to 17.

Henry capped the scoring with a 10-yard TD run with 7:13 left in the game, sending thousands of Patriots fans heading for the exits.

Tom Brady operated under pressure almost all day, completing 21 of 41 passes for 254 yards. Tennessee sacked him three times and pressured him on a number of other throws before coach Bill Belichick lifted him for Brian Hoyer after Henry's final score.

Davis caught seven passes for 125 yards to lead the Titans, while Julian Edelman tallied nine receptions for 104 yards in a losing cause.

--Field Level Media