Fred Jackson piled up 196 yards from scrimmage and the Buffalo Bills defense picked off Michael Vick four times en route to a 31-24 victory over the visiting Philadelphia Eagles on Sunday.

Ryan Fitzpatrick completed 21 of 27 passes for 193 yards and a touchdown to David Nelson for the Bills (4-1), who bounced back from their first loss last weekend.

The Eagles (1-4) have lost four straight games for the first time since 2005.

Vick finished with 315 yards passing and added 90 yards on the ground to pass Randall Cunningham for first place on the all-time rushing list among quarterbacks.

After blowing big leads in its previous losses, Philadelphia was looking to finish strong against Buffalo. Instead, the Eagles started out with a slew of errors.

Vick was intercepted on their first two drives, with the Bills cashing in the first pick for seven points with Jackson’s 5-yard touchdown run.

Fitzpatrick and Nelson made it 14-7 in the second, and Vick was picked off on the first play of the ensuing drive by Nick Barnett, who returned it 31 yards for a touchdown.

It was 28-7 early in the third when Philadelphia tried to rally, pulling within a touchdown on Alex Henery’s 35-yard field goal with 9:29 left.

The Eagles were driving to tie it with under two minutes remaining when Vick was picked off by Barnett again.