Jett Duffey passed for 424 yards and accounted for five touchdowns in his fourth career start as Texas Tech upset No. 21 Oklahoma State 45-35 on Saturday afternoon in Lubbock, Texas.

The junior completed 26 of 44 passes with four TD tosses in his second career 400-yard game, and wide receiver T.J. Vasher caught five passes for 110 yards and a score for the Red Raiders (3-2, 1-1 Big 12).

Texas Tech's defense recorded five turnovers after forcing four total in the first four games and added seven sacks.

Douglas Coleman III had two interceptions, giving him an FBS-leading five for the season.

The victory snapped a 10-game home losing streak against ranked opponents for the Red Raiders, dating back to a 2013 win against TCU.

OSU's Chuba Hubbard, the nation's leading rusher coming in, notched 156 yards on 34 carries with three scores and pushed his season total to 1,094 yards and 13 TDs.

Spencer Sanders completed 22 of 37 passes for 290 yards and two scores but added three interceptions for the Cowboys (4-2, 1-2).

Trey Wolff put Texas Tech up 3-0. His 38-yarder came after Broderick Washington Jr. recovered a fumble by Sanders on a sack on the game's opening series.

Making his second straight start in place of injured quarterback Alan Bowman, Duffey scrambled and sliced his way past defenders on a 16-yard scoring run at 5:01 for a 10-0 lead.

Wolff punched home a 27-yard field goal at 1:03.

Duffey capitalized on Coleman's first pick with a 14-yard lob to KeSean Carter at 10:21 to go up 20-0.

Hubbard finally put OSU on the board with a hard 3-yard run with 30 seconds left in the half.

Duffey opened the second half with a 21-yard score to Vasher, but Sanders answered 62 seconds later with a 73-yard strike to Jordan McCray to make it 27-14.

Dalton Rigdon hauled in a pass for 8 yards from Duffey for a 34-14 lead at 5:48, but Hubbard followed with his second rushing TD three minutes later.

Wolff nailed a 26-yarder early in the fourth quarter and Erik Ezukanma grabbed a 56-yard TD before Hubbard scored for the third time.

OSU's Tylan Wallace (11 catches, 85 yards) caught a 10-yard TD pass from Sanders for the final margin.

--Field Level Media