Minnesota at Chi. White Sox 2:10 PM ET
After a dreadful season-opening series, the visiting Minnesota Twins will look to earn their first win of the season Monday afternoon when they open a three-game series at the Chicago White Sox.
Kansas City at Milwaukee 2:10 PM ET
The Milwaukee Brewers will be looking to put a brutal season-opening road sweep behind them when they open their home campaign against the Kansas Royals on Monday.
Boston at Baltimore 2:35 PM ET
An uptick in offense will be one of the first orders of business when the Boston Red Sox and Baltimore Orioles meet Monday afternoon for the opener of a three-game series.
Colorado at Philadelphia 3:05 PM ET
As good as Philadelphia Phillies left-hander Cristopher Sanchez was last season, there is every reason to believe this year could be better.
Texas at Cincinnati 6:40 PM ET
After taking three of four games in their season-opening series, the Texas Rangers will hit the road for the first time in 2025 when they face the Cincinnati Reds on Monday evening.
NY Mets at Miami 6:40 PM ET
The Miami Marlins hope to continue their flair for the dramatic on Monday evening when they open a three-game series against the visiting New York Mets, a team that has enjoyed no such late-game fireworks so far.
Pittsburgh at Tampa Bay 7:05 PM ET
Fully recovered from an elbow procedure that cost him much of the 2023 and 2024 seasons, Tampa Bay right-hander Drew Rasmussen will return to the rotation for good Monday night when the Rays open a three-game home series with the Pittsburgh Pirates.
Washington at Toronto 7:07 PM ET
The notion that the Washington Nationals have turned on the power switch will be tested again Monday night when they visit the Toronto Blue Jays in the opener of a three-game series.
LA Angels at St. Louis 7:45 PM ET
St. Louis Cardinals right-hander Miles Mikolas is in the final season of a three-year, $55.75 million contract, so he faces an uncertain future with his team in transition.
San Francisco at Houston 8:10 PM ET
While right-hander Spencer Arrighetti capped a strong opening weekend for the Houston rotation on Saturday, it was the performance of the Astros' bullpen that raised eyebrows.
Cleveland at San Diego 9:40 PM ET
Consider the bar set pretty high for San Diego Padres left-hander Kyle Hart.
Detroit at Seattle 9:40 PM ET
Detroit's Jackson Jobe already has pitched in a playoff game.
Chi. Cubs at Athletics 10:05 PM ET
The Athletics formally begin the home portion of their Sacramento era when they host the Chicago Cubs on Monday night in the first-ever Major League Baseball game in the California capital.
Atlanta at LA Dodgers 10:10 PM ET
Opposites will attract Monday night when the red-hot Los Angeles Dodgers host the slow-starting Atlanta Braves in the opener of a three-game series.