Marlon Mack rushed for 132 yards on 29 carries Sunday as the Indianapolis Colts controlled the clock with a potent run game and shocked the Kansas City Chiefs 19-13 at Kansas City, Mo.

Mack led a 180-yard ground attack that enabled the Colts (3-2) to control the football for 37-plus minutes on 45 rushes. They kept Patrick Mahomes and the high-powered Chiefs (4-1) from finding any rhythm in handing them their first loss of the season.

Mahomes turned his ankle in the first half and aggravated the injury while playing on it in the second half. He passed for 321 yards but was sacked four times. The Chiefs committed 11 penalties for 125 yards and scored just three points over the final 44-plus minutes.

The outcome left the New England Patriots (5-0) and San Francisco 49ers (3-0) as the only unbeaten teams in the NFL.

Justin Houston, a former All-Pro linebacker for Kansas City, helped the Colts' defensive effort, recording a fourth-down tackle to stop the Chiefs at their 33 with 5 minutes left in the fourth quarter. The young Colts defense played without two starting safeties and last year's Defensive Rookie of the Year in the NFL, linebacker Darius Leonard.

Indianapolis quarterback Jacoby Brissett engineered the upset, completing 18 of 29 passes for 151 yards.

Adam Vinatieri booted four field goals, including a pair of 32-yarders in the first half -- the second coming with 10 seconds left to give Indianapolis a 13-10 halftime lead.

Mahomes started fast, going 8 of 9 on the first possession, but a penalty and failure to convert on third-and-long forced Kansas City to settle for a 29-yard field goal from Harrison Butker. The Chiefs' only touchdown came when Mahomes scrambled and found Byron Pringle for a 27-yard touchdown on a third-and-18 call early in the second quarter.

Chiefs cornerback Bashaud Breeland was flagged for three first-half penalties, including a 53-yard pass interference call that put Vinatieri in position for his first field goal.

The Colts also drove 70 yards for a first-quarter touchdown on a 1-yard keeper by Brissett after Mack got going with 40 yards rushing on that march.

--Field Level Media