Colts 23, Jaguars 3: T.Y. Hilton had 122 receiving yards and a touchdown and Adam Vinatieri booted three field goals as host Indianapolis beat Jacksonville for the fifth straight time.

Andrew Luck finished 21-of-32 for 253 yards and a touchdown and rushed for 49 yards on eight carries for the Colts (7-4), who have won seven straight home games against AFC South opponents. Daniel Herron rushed for 65 yards on 12 attempts and Trent Richardson added 42 yards and a touchdown in Indianapolis' first game since leading rusher Ahmad Bradshaw was lost for the season with a broken ankle.

Rookie Blake Bortles struggled for the Jaguars (1-10), going 15-of-27 for 146 yards with an interception and taking four sacks. Toby Gerhart led the ground game with 31 yards on four carries and Marqise Lee had three receptions for 52 yards for Jacksonville, which has lost four straight.

Vinatieri and Josh Scobee traded field goals in the first quarter before Vinatieri tacked on a 20-yard kick with 12 seconds left in the half to send Indianapolis to the break with a 6-3 lead. The Colts took advantage of a short field after an 18-yard Josh Cribbs punt return and Richardson punched in a 1-yard score to make it 13-3 with 8:31 left in the third.

Luck and Hilton burned the Jacksonville secondary for a 73-yard touchdown on the Colts' next possession to put it out of reach, and Vinatieri added a 32-yard field goal to cap the scoring. The Colts overcame six fumbles - three lost - and five sacks.

GAME NOTEBOOK: Luck saw the end of his streak of eight consecutive 300-yard passing games, which was the third-longest string in NFL history. … Vinatieri has made 31 consecutive field goals, including all 25 attempts this season. … Hilton surpassed 1,000 yards receiving for the second consecutive season.