Colts 24, Dolphins 20: Ryan Tannehill threw for 319 yards and a touchdown and visiting Miami made two big defensive stops in the fourth quarter to snap a four-game losing streak at the hands of Indianapolis.

Mike Wallace had nine catches for 115 yards and a touchdown while Charles Clay added five receptions for 109 yards and scored the go-ahead TD on a 1-yard plunge in the third quarter for the Dolphins (2-0).

Colts quarterback Andrew Luck, who has led eight comebacks in the fourth quarter and overtime in his brief career, finished 25-of-43 for 321 yards and a touchdown, but he threw a costly interception in the end zone with just over eight minutes to play. Indianapolis' last gasp was snuffed out when Luck was sacked at the Colts' 28-yard line with 1:27 remaining.

The Colts took their last lead with just over 11 1/2 minutes to play in the third quarter on Adam Vinatieri's 38-yard field goal following a questionable fumble by Tannehill, who was 23-of-34. The Dolphins answered with a six-play, 69-yard drive that featured a 34-yard pass to Wallace to the Indianapolis 1 before Clay went in for the go-ahead touchdown with 4:40 left in the third.

Miami scored on its first two possessions, getting an 18-yard touchdown pass from Tannehill to Wallace and a 10-yard run by Lamar Miller for a 14-3 lead. The Colts went ahead on Luck's 3-yard pass to tight end Coby Fleener early in the second quarter and Ahmad Bradshaw's 1-yard burst before Dolphins rookie Caleb Sturgis nailed a 54-yard field goal on the final play of the half to forge a 17-17 tie.

GAME NOTEBOOK: Wallace, the pricey free-agent acquisition who complained about his role in the offense after having only one catch for 15 yards in the season opener, went over 100 yards for only the third time in 26 games. ... Colts second-year WR T.Y. Hilton, playing in his 17th career game, had his sixth 100-yard performance to move into a tie for 10th place on the franchise list. ... Colts LG Donald Thomas, a former Dolphin, exited the game in the first quarter with a right knee injury and WR Darrius Heyward-Bey suffered a rib injury.