Louisville finally broke its Big East Conference road losing skid, while Syracuse doesn't appear to feel at home in the dome.

Jeremy Wright ran for two touchdowns and Justin Burke threw for a pair of scores to lead Louisville to a 28-20 victory over Syracuse on Saturday at the Carrier Dome.

Louisville (5-4, 2-2 Big East) had lost its last 11 conference road games and had not beaten a Big East team on the road since a 28-24 win over Cincinnati in 2007.

Coming in it looked like the Cardinals would be headed for another road loss with star running back Bilal Powell sidelined with a knee injury and starting quarterback Adam Froman out with a leg injury.

But Wright and Burke picked up the slack.

Wright's second touchdown of the game, a 12-yarder early in the third quarter, gave the Cardinals a 21-17 lead. Burke helped ice the game in the fourth, throwing a 21-yard scoring strike to Josh Chichester on the first play of the quarter. Burke then picked up a crucial first down with a quarterback sneak on 4th-and-inches from the Louisville 40 with just over three minutes to play and the Orange out of timeouts.

Syracuse (6-3, 3-2) has now suffered both of its conference losses at home. The Orange were trounced by conference-leading Pittsburgh, 45-14, on October 16 but entered Saturday coming off road wins over West Virginia and Cincinnati.

Delone Carter rushed for 107 yards and a touchdown on 21 carries for Syracuse, which held a 17-14 lead at the half.