LOS ANGELES -- Third baseman Alex Guerrero hit a game-winning single with two outs in the 10th, giving the Los Angeles Dodgers a 6-5 victory over the Seattle Mariners before a crowd of 42,202 at Dodger Stadium on Monday night.

Center fielder Andre Ethier led off the 10th with a double. After right fielder Yasiel Puig bounced a comebacker to reliever Dominic Leone, the Mariners intentionally walked first baseman Adrian Gonzalez. Second baseman Howie Kendrick drew a pass to load the bases, but reliever Tyler Olson struck out left fielder Carl Crawford.

Guerrero followed with his game-winning hit, the first walk-off of his career.

Reliever Yimi Garcia (1-0) retired the side in the 10th as the Dodgers (4-3) won their second in a row.

Leone (0-1) gave up a run in 2 1/3 innings for Seattle (3-4).

Seattle right fielder Nelson Cruz homered twice in the loss.

Dodgers starter Brandon McCarthy struck out 10 with no walks, but gave up five runs, including four home runs, on six hits. After allowing a home run to center fielder Dustin Ackley, McCarthy retired 10 of the last 11 Mariners he faced, allowing a walk to Ackley in the eighth.

Seattle left-hander James Paxton allowed five runs on six hits with six strikeouts and two walks in 6 1/3 innings. Paxton retired nine of the 10 batters he faced before Puig recorded the first Dodgers hit off him to lead off the fourth. Puig also homered off Paxton in the fifth.

After a single by second baseman Robinson Cano, Cruz drove a 1-2 McCarthy pitch into the seats in right for a 2-0 Mariners lead with two outs in the first inning.

Cruz homered again with one out in the fourth, hitting a 1-0 pitch by McCarthy that just cleared the wall in right for a solo shot. Third baseman Kyle Seager followed with another blast to right for a 4-0 Seattle lead.

The Dodgers, though, cut the deficit with three runs in the bottom of the inning. A sacrifice fly by third baseman Alex Guerrero brought home Gonzalez. Center fielder Joc Pederson smacked a two-run single to left, scoring second baseman Howie Kendrick and left fielder Scott Van Slyke, pulling Los Angeles within 4-3.

However, Ackley took McCarthy deep with a solo home run to center with two outs in the fifth to give Seattle a 5-3 advantage.

Puig ripped a solo homer to left on the first pitch from Paxton with two outs in the fifth to cut the Mariners' lead to one again. Kendrick's RBI single to right scored Gonzalez and tied the score at 5.

NOTES: The Mariners placed RHP Tom Wilhelmsen on the 15-day disabled list with a hyperextended right elbow and recalled RHP Dominic Leone from Triple-A Tacoma. ... Mariners RF Nelson Cruz led the major leagues with nine home runs during interleague play in 2014. ... Dodgers SS Jimmy Rollins and LF Carl Crawford were not in the starting lineup. Darwin Barney started for Rollins, while Scott Van Slyke got the nod over Crawford. ... The Dodgers released RHP Ryan Webb on Monday. Webb was obtained by the club in a trade last week with the Baltimore Orioles. ... Mariners RHP Hisashi Iwakuma (0-1, 6.00 ERA), who lost to the Los Angeles Angels in his initial start, will face Dodgers LHP David Huff (0-0, 0.00 ERA) on Tuesday.