TORONTO -- Aaron Sanchez tried to slip one more fastball past Carlos Beltran in the eighth inning on Friday.

The Toronto Blue Jays right-handed reliever did not get the four-seamer where he wanted it this time. It was right where Beltran could hit it.

The New York Yankees pinch-hitter hammered the 1-2 pitch to right center for a three-run homer.

It was enough for a 4-3 victory Yankees victory to end the Blue Jays' 11-game winning streak even though Toronto had runners at second and third with one out in the ninth.

"With the (noisy sellout) crowd in the stands I was a little amped up," Sanchez (6-5) said. "And I saw that I threw the first pitch by him, it was elevated, so I was just trying to attack there the whole at-bat. The fourth pitch, to me, seemed like it was right over the plate. The moral of the story is I didn't get my job done, and it cost us a win."

Beltran's homer capped a four-run eighth for the Yankees (63-51), who regained a half-game lead over the second-place Blue Jays (64-53) in the American League East.

"As soon as I hit it, I knew it was going to leave the ballpark," Beltran said. "It's a good feeling being able to come off the bench and come through and help the team win a ball game."

Yankees right-hander Ivan Nova (5-4) overcame a three-run third inning for the victory. Nova allowed five hits, one walk and three runs in seven innings. He also hit two batters and struck out three.

Blue Jays left-hander David Price allowed 11 hits, no walks and three runs in 7 1/3 innings and did not factor in the decision. He struck out six.

"We knew those guys were going to be ready to play tonight," Price said. "They snuck it in late. That's part of it. A loss like this can definitely bring your team closer whenever it happens like that. In this situation I know that we're going to come ready to win tomorrow."

Price did not allow a run until the eighth when he gave up three straight hits with one out as he tried for his third win in as many starts since he was acquired in a trade with the Detroit Tigers on July 30.

Yankees first baseman Mark Teixeira and catcher Brian McCann singled with one out in the eighth. Third baseman Chase Headley hit an RBI double. Sanchez replaced Price before Beltran, batting for right fielder Chris Young, hit his 11th homer of the season.

"It was a tough decision no question about it," Blue Jays manager John Gibbons said. "It backfired. I felt good about putting Sanchy in. It didn't work. When those don't work, you analyze them, that's for sure."

Yankees right-hander Dellin Betances pitched the eighth and left-hander Andrew Miller worked a nervous ninth to pick up his 26th save of the season.

Pinch-hitter Chris Colabello walked with one out in the ninth and Cliff Pennington ran for him. Center fielder Kevin Pillar singled to send Pennington to second.

A wild pitch moved the runners to second and third. Left fielder Ben Revere struck out to bring up shortstop Troy Tulowitzki with two outs, but he struck out on a 3-2 pitch to end the game after fouling off several tough pitches in a 12-pitch at-bat.

"It was a great battle but Andrew got a big strikeout," Yankees manager Joe Girardi said. "Hopefully it gives us confidence. We went through a tough streak there offensively. I thought we did a pretty good job against a really good pitcher in David Price."

"The whole inning was such a grind," Miller said. "I felt like I was making pitches and I thought I had good stuff.

Great all around win, glad I was able to nail it down. It wasn't pretty. That was a playoff atmosphere. These fans are insane right now and rightfully so."

The Blue Jays scored three runs in the third to build their lead.

Pillar reached first base to lead off the inning when he was hit by an 0-2 curveball. Revere singled to send Pillar to third with the Blue Jays' first hit of the game. Tulowitzki's grounder up the middle was deflected by Nova to Yankees shortstop Didi Gregrorius, who got the force at second base as Pillar scored the first run.

Third baseman Josh Donaldson then singled to left and right fielder Jose Bautista smacked an RBI double to left. Designated hitter Edwin Encarnacion lifted a sacrifice fly to center.

NOTES: Toronto DH Edwin Encarnacion (sore finger) returned to the lineup on Friday after missing four straight games. He extended his hitting streak to 12 games with a one-out double in the sixth inning. ... RHP Joba Chamberlain was released at Triple-A Buffalo on Friday. The Blue Jays signed the 29-year-old to a minor league contract on July 21 after the former Yankees reliever was released by the Detroit Tigers. ... On Thursday, LHP Andrew Miller became the first Yankees left-hander with 25 saves in a season since Dave Righetti accomplished it in seven straight years (1984-90). ... RHP Michael Pineda (right forearm strain) had a bullpen session Thursday and could return to the Yankees' rotation after a rehabilitation start with Double-A Trenton on Sunday. ... New York RHP Masahiro Tanaka (8-5, 3.79 ERA) will start the second game of the three-game series on Saturday against Toronto RHP Marco Estrada (10-6, 3.21).