OAKLAND, Calif. -- Third baseman Brett Lawrie hit a three-run homer and right-fielder Josh Reddick added a solo shot as the Oakland A's ended their four-game losing streak with a 6-2 victory against the Los Angeles Angels on Tuesday night at the O.co Coliseum.

A's right-hander Sonny Gray gave up two runs on six hits over eight innings and improved to 3-0, winning the opener of a three-game series. He struck out six, walked one and beat the Angels for the second time this season, in back-to-back starts. Gray held them to one run and two hits over seven innings in a 9-2 A's victory on April 22 at Angel Stadium.

Gray gave up two runs in the first inning then pitched six straight shutout frames.

Angels right-hander Jered Weaver fell to 0-3, giving up six runs on six hits, including two home runs, over seven innings. Weaver is winless through his first five starts for the first time in his career.

Lawrie capped a five-run A's outburst in the first inning with a three-run blast off Weaver, his second home run of the season.

Then with two outs in the sixth, Reddick hit his second home run of the season, launching a Weaver pitch deep to right with two outs. Reddick went 2-for-4 with three RBIs and scored twice.

Third baseman David Freese drove in both Angels runs with a first-inning single.

The A's won for just the fourth time in 11 games in Oakland.

The Angels struck first taking a 2-0 lead in the top of the first inning. Right fielder Kole Calhoun led off against Gray with a walk and moved to third on first baseman Albert Pujols' one-out single. Pujols went to second on a wild-pitch, and Freese lined a two-run single to center.

Oakland answered with five runs in the bottom of the first. With one out, shortstop Marcus Semien hit an infield single then went to third on catcher Stephen Vogt's single to center. Weaver hit designated hitter Billy Butler with a pitch, loading the bases.

Weaver retired first baseman Ike Davis on a pop up, but Reddick ripped a two-run single to right-center, making it 2-2 and bringing Lawrie to the plate.

Lawrie crushed Weaver's first pitch, a belt high 84 mph fastball, into the left-field seats for a three-run homer.

NOTES: One day after the Angels traded OF Josh Hamilton to Texas, manager Mike Scioscia said he was "concerned with Josh the person" as he battles drug and alcohol problems, but was also disappointed that Hamilton didn't publicly acknowledge the support he received from his teammates. "I know that he got a lot of support from the guys that are in that clubhouse and him not to show at least a little remorse toward his teammates I just think is wrong," Scioscia said. ... Angels C Chris Iannetta was out of the lineup because of a cut on a finger he sustained when throwing his bat after making an out Sunday against Texas, Scioscia said. "He got a little upset. He'll play tomorrow," Scioscia said. ... A's RHP Jesse Hahn, who skipped his previous start because of blister on his right middle finger, will start Wednesday against the Angels. ... Oakland RHP Jesse Chavez, who replaced rookie right-hander Kendall Graveman in the rotation, will start Thursday against the Angles, and LHP Scott Kazmir's start was pushed back to Friday at Texas. ... A's CF Coco Crisp (right elbow surgery) took swings off a tee and expects to start a rehab assignment sometime during the Class A Stockton Ports' homestand, May 1-7. ... A's LHP Sean Doolittle (strained left shoulder) pitched off a mound for the first time since his injury, throwing 21 pitches, all fastballs.