MINNEAPOLIS -- With designated hitter Kennys Vargas leading the way, the Minnesota Twins' scuffling offense got back on track Monday.

The Twins pounded out 13 hits and matched their season-high run total in a 13-2 win over the White Sox at Target Field.

Vargas had a career-high four hits, including a massive three-run homer in the sixth inning to help break the game open. His four RBIs were also a season high.

Minnesota hit a season-high four homers and roughed up White Sox starter John Danks for nine runs (five earned) in 5 1/3 innings, scoring double-digit runs for the first time since May 6.

The Twins entered the night averaging 2.75 runs per game in June, going 7-13 in that span and failing to score more than two runs in 10 of those games. They improved to 8-3 against the White Sox this season. Minnesota is 5-0 at home against Chicago, outscoring the White Sox by a 44-10 margin in those games.

Minnesota wasted no time in getting on the board Monday, scoring once in the first before adding five runs in the fourth, five in the sixth and two more in the eighth.

"Just to have an outbreak like that, that was pretty cool. It felt good," Twins right fielder Torii Hunter said. "Hopefully, we can kind of maintain that. It's hard to do that every night. You just have to ride that wave till it ends."

Twins shortstop Eduardo Nunez hit his second homer of the season and first baseman Joe Mauer hit his fourth. Center fielder Byron Buxton had three hits, his first multi-hit game as a big-leaguer. Second baseman Brian Dozier added two hits, including a two-run homer.

"A lot of guys had good nights offensively," Twins manager Paul Molitor said. "There was just a lot of contribution. That's going to happen when you get 13 runs."

Twins left-hander Tommy Milone (4-1) tossed six innings of two-run ball. He allowed 10 hits, walked two and struck out two.

Danks (3-8) fell to 7-15 with a 5.76 ERA in 29 career games against the Twins. He gave up nine hits, including three homers, walked one and struck out two.

"I stunk, there's really no other way to put it," Danks said. "I wasn't good in the bullpen, wasn't good in the game, made bad pitches, got hit. Gotta throw early strikes, gotta get ahead and make quality pitches, and I did neither."

Chicago committed three errors while losing for the ninth time in 11 games. The loss snapped a brief two-game winning streak.

"That was frustrating, but it wasn't the reason for the game," White Sox manager Robin Ventura said of the defensive troubles. "It's an unfortunate one, but you gotta be able to come back and bounce back from that."

Buxton led off the first with a double into the right-center-field gap. He scored when Dozier followed with a single to left, giving Minnesota an early 1-0 lead.

The White Sox took a 2-1 lead in the third thanks to three hits and a walk, all with two outs. A single by right fielder Avisail Garcia, a double by first baseman Jose Abreu and a walk to left fielder Melky Cabrera loaded the bases for designated hitter Adam LaRoche, who ripped a two-run single to center.

Shortstop Alexei Ramirez followed with another single to center, but Buxton threw out Cabrera trying to score from second for the final out of the inning.

"I try to take away as many base hits and keep runners off base as much as I can," Buxton said. "I overthrew the cutoff man, but I saw him rounding third when I got the ball, so I just tried to make a good throw."

Minnesota posted a crooked number of its own in the fourth inning, taking advantage of two Chicago errors to take a 6-2 lead.

A solo homer by Mauer tied the score at 2 before a walk, an error on a fielder's choice and another error on a fly ball to left put runners on second and third with one out.

Catcher Kurt Suzuki drove in a run with a sacrifice fly. Vargas singled to left-center, increasing the margin to 4-2. Nunez, the Twins' No. 9 hitter, jerked a two-run shot into the upper deck in left.

Four of the five runs off Danks in the inning were unearned.

NOTES: White Sox LHP Dan Jennings began a rehab assignment with Triple-A Charlotte on Monday, allowing one run in two innings. Jennings, 1-2 with a 7.83 ERA in 22 appearances this season, landed on the 15-day disabled list June 5 due to neck inflammation. ... Twins RF Torii Hunter batted cleanup against White Sox LHP John Danks. Hunter entered the game with a .327 career average against Danks with four homers and 11 RBIs in 52 at-bats. He went 0-for-2 with a walk before hitting a two-run double after Danks exited. ... Twins CF Byron Buxton was in the leadoff spot. It was the first time in Buxton's big-league career that he hit outside of the No. 9 hole. ... The White Sox and Twins will play the second of the three-game series Tuesday night at Target Field. Chicago RHP Jeff Samardzija (4-4, 4.67 ERA) will oppose Minnesota RHP Mike Pelfrey (3-2, 3.05 ERA).