Jeremy Guthrie allowed one run in seven innings to lift the visiting Baltimore Orioles to a 4-2 victory over the New York Yankees on Friday night.

Guthrie (5-14) broke an eight-game road losing streak, winning for the first time away from home since opening day.

Mark Reynolds hit a two-run homer and Derrek Lee added a solo homer and RBI double for the Orioles, who beat the Yankees for the first time in seven games this season.

A.J. Burnett (8-9) struck out a season-high 10 in eight innings but fell to 0-3 in his last five starts. He allowed four runs on five hits.

Mark Teixeira hit his team-high 29th homer of the season and third in four games to account for New York's first run.

Kevin Gregg gave up a run in the ninth before securing his 17th save.

Reynolds staked the Orioles to a 2-0 lead with a two-run blast off Burnett in the third. Reynolds, the team leader with 22 homers, went deep for only the second time in his last 20 games.