TORONTO -- The struggling Tampa Bay Rays needed that.

They needed the first win of the season by Blake Snell. They needed the return of a long dormant offense that provided two home runs.

With Snell winning for the first time since Sept. 22, Lucas Duda hitting a two-run homer and Wilson Ramos adding a solo shot, the Rays defeated the Toronto Blue Jays 6-4 on Tuesday night.

"We needed that win," Rays manager Kevin Cash said. "Looking at all (Snell's) starts, you could probably make the argument that that might have been his best one. I thought his stuff was really good. It was outstanding to get some runs on the board. The guys felt really good."

The Rays had scored only 12 runs in their previous 10 games, losing eight of them.

Snell (1-6) allowed seven hits, one walk and four runs while striking out four in six innings.

"Everyone was hitting well and having good at-bats," Snell said. "It's been tough."

Alex Colome earned his 35th save with a perfect ninth, striking out two.

The Rays (60-61) ended a four-game losing streak as the teams split the first two contests of a four-game series.

Josh Donaldson hit a three-run homer for the Blue Jays (57-62), who had a three-game winning string stopped.

Marco Estrada (5-8) allowed six runs, 10 hits and four walks in 4 1/3 innings. He struck out three.

He has an ERA of 7.75 and is 0-7 in his past eight starts against Tampa Bay.

"Just one of those teams that has my number," Estrada said. "I haven't been able to figure them out. I felt OK today and thought I did make some decent pitches and next thing you know I'm down six runs."

The Blue Jays scored a run in the second inning when Steve Pearce singled and came home on a double by Kevin Pillar that took a big bounce over right fielder Steven Souza Jr.

Duda hit his 21st homer of the season -- his fourth since joining the Rays in a trade with the New York Mets on June 27 -- two batters after Daniel Robertson singled in the third to put the Rays into a 2-1 lead.

Ramos led off the fourth with his fifth homer of the season, his second of the series. Adeiny Hechavarria blooped a double down the right field line that fell among three fielders and scored on Corey Dickerson's single to give the Rays a 4-1 lead.

Tampa Bay built its lead to 6-1 in the fifth on singles by Logan Morrison, Souza and Ramos, the latter a fly ball that center fielder Pillar lost in the twilight, and bases-loaded walks to Hechavarria and Robertson.

The Blue Jays failed to get the double play on a line drive to second by Mallex Smith. Second baseman Rob Refsnyder flipped to shortstop Darwin Barney, who failed to control the ball, when Morrison appeared to be doubled up at second. At first it was ruled a double play but a video review overturned the call and Morrison was safe.

"I'm upset at myself for letting it get to me," Estrada said. "I know everybody's trying hard, I'm trying hard. Everybody knows that team has given me a hard time and when some of those plays aren't made, it's hard to let it go sometimes. Normally, I don't really think about that stuff, I let it go... today it obviously affected me and I walked the next two guys, walked two guys in. There's no excuse for that."

"I thought he had pretty good stuff tonight," Gibbons said. "But, for whatever reason, it's been a tough matchup. We had a tough inning. We didn't turn two on that ball, the line drive. And Kevin (Pillar) lost (the single) in the twilight, it's a tough sky, it happens. Overall it didn't look good, but his stuff was good."

Matt Dermody replaced Estrada to get the final two outs of the fifth.

The Blue Jays scored three on Donaldson's 18th homer in the bottom of the fifth. The blast also scored Barney, who singled with one out, and Jose Bautista, who followed with a double.

"That's what they do, they work, they grind," Snell said. "You can't shut them out forever."

NOTES: Rays OF Steven Souza Jr. has 25 homers this season, all against right-handed pitchers. He is the first right-handed hitter in the expansion era (starting in 1961) to hit his first 25 homers of the season against right-handers. Souza went 2-for-4 with a double Tuesday. ... Toronto 3B Josh Donaldson hit his ninth first-inning homer of the season Monday. ... Toronto RHP Nick Tepesch earned the win Monday without striking out a batter in six-plus innings. It was the first time a Blue Jays starter had won without a strikeout while pitching at least six innings since RHP R.A. Dickey did it May 14, 2015, against the New York Yankees. ... Rays RHP Jake Faria (5-3, 3.19 ERA) opposes Blue Jays RHP Marcus Stroman (10-6, 3.00) on Wednesday.