SAN DIEGO -- Right-hander Odrisamer Despaigne held Arizona to one run on two hits over seven innings and left fielder Justin Upton hit a home run Tuesday night as the San Diego Padres defeated the Diamondbacks 5-1 at Petco Park.

Despaigne, working in the rotation slot of the injured Ian Kennedy, needed only 84 pitches to complete seven innings in his first start -- and first win -- of the season.

After losing the No. 5 spot in the Padres rotation to Brandon Morrow this spring, Despaigne set a Padres record by pitching 4 2/3 perfect innings of relief last Thursday after Kennedy suffered a mild strain of his left hamstring.

In addition to allowing two hits, he issued two walks and hit a batter, which led to Arizona's lone run. He struck out only two Diamondbacks while getting nine ground-ball outs.

Arizona starter Jeremy Hellickson (0-2) took the loss, allowing five runs on seven hits and three walks over 6 2/3 innings.

The Padres scored three times in the first inning off Hellickson.

Center fielder Wil Myers hit a leadoff double off the base of the wall in right-center and moved to third on second baseman Yangervis Solarte's infield single that rolled past Hellickson.

Myers scored when right fielder Matt Kemp grounded into a forceout of Solarte at second.

Upton drew a walk, and catcher Derek Norris lined a double into the left field corner that scored Kemp with the second run. Upton scored when first baseman Yonder Alonso grounded out to first.

The Diamondbacks got on the board in the fourth when left fielder David Peralta was hit by a Despaigne pitch and scored on right fielder Mark Trumbo's double.

The Padres got the run back in the bottom of the fifth on one swing by Upton.

Upton rocketed a 79 mph changeup from Hellickson 389 feet into the second deck at Petco Park. Upton's second home run of the season extended his hitting streak to nine games this season and 11 games dating back to the end of 2014.

NOTES: Padres switch hitter Yangervis Solarte started his third consecutive game at second base as slumping Jedd Gyorko worked on the side with hitting coaches Mark Kotsay and Alonzo Powell. ... San Diego RHP Ian Kennedy is scheduled to throw a bullpen Wednesday, just six days after going on the disabled list with a mild strain of the left calf. ... Although he was 9-for-20 in his past five games and off to a .393 start, Arizona OF Ender Inciarte got Tuesday off. ... The game opened with two former American League Rookies of the Year with Tampa Bay facing each other -- Arizona RHP Jeremy Hellickson (2011) and Padres CF Wil Myers (2013). Myers doubled off the base of the wall in right-center.